ABSTRACT
Background: Endocrine therapy for breast cancer is directed at reducing oestrogen synthesis or alternatively blocking oestrogen receptors (ER) in tumour-sensitive tumors. Despite side effects, the use of systemic adjuvant therapy after local management of breast cancer substantially improves survival and reduces the risk of relapse. The study objective was to assess the recurrence of breast cancer and the complications seen in breast cancer patients on tamoxifen therapy at a hospital-based cancer registry, Thrissur, Kerala.Methods: After obtaining institutional ethical clearance, included 75 patients of histologically diagnosed breast carcinoma currently on tamoxifen, diagnosed in the year of 2016. Data was obtained from the patient files and by personal intimation.Results: Of the 75 patients on tamoxifen, four (5.33%) patients had history of recurrence. 22.6% of patients on tamoxifen were noted to have increased endometrial thickness. Other side effects noted were weight gain, TIA, bone pain and vaginal discharge.Conclusions: It was found that the recurrence rate at three years for the study population was 5.33%. More studies from developing countries, with larger sample size and clinical trials will give us more accurate information regarding the efficacy of the drug.
ABSTRACT
Background: Nursing binds human society with a bond of care and affection. Nurses are often the first healthcare professional that patients meet. Quality of care for patients is strongly linked to the performance of the nursing staff. If the mental health status of these nurses is troubled, then they will not be able to give their full attention to this demanding task. Nowadays, all efforts to fight health workers’ illnesses are extremely important. This descriptive cross-sectional study will give us knowledge regarding the anxiety and depression status among nurses and give the nursing staff an opportunity to express their difficulty in professional life working in a tertiary care hospital in South India. Objective of this study was conducted to assess the prevalence of anxiety and depression among nurses working in a tertiary care hospital and to assess the correlation between various factors influencing the level of anxiety and depression among nurses.Methods: Nurses were selected by simple random sampling till the sample size was obtained. A standardised questionnaire was handed over to the participants to collect relevant data and was assessed by Hospital Anxiety and Depression Score (HADS) and analysed using SPSS software.Results: The participants consist of 120 nurses. The study gives frequencies of nurses with anxiety as 48(40%) and depression as 43(35.8%). There does not exist any significant correlation of anxiety and depression with various factors influencing them.Conclusions: Anxiety and depression levels are increased in the younger and less experienced nurses. Thereafter, interventions can be planned to improve the quality of work-life of nurses that can improve patient care and in turn benefit the society.